Protein Alignment E(spl)m8-HLH and Hes6

DIOPT Version :9

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_062352.1
• Gene: Hes6 / 55927
• MGIID: 1859852
• Length: 224
• Species: Mus musculus
• Alignment Length: 208
• Identity: 53/208 - (25%)
• Similarity: 89/208 - (42%)
• Gaps: 48/208 - (23%)

  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVAQEE 75
            :|.:||::|::||||:|:.|..|:.|:|   |.:...:::.||:||..|  .|.|...:..|:|.
Mouse    26 RKARKPLVEKKRRARINESLQELRLLLA---GTEVQAKLENAEVLELTV--RRVQGALRGRARER 85

  Fly    76 QSLPLDS---FKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQ 137
            :.|..::   |..||:..::||...:::...:...:...::.||    .......|..|..|.:.
Mouse    86 EQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHL----LESMPLREGSSFQDLLG 146

  Fly   138 NSM-------DCSSMDK--APLSPASS--GYHSDCDS-------------PAPSPQPMQ------ 172
            :|:       ..||...  :|.||.||  |...|..|             ||..|..:.
Mouse   147 DSLAGLPGGSGRSSWPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVSTSLGSL 211

  Fly   173 ------QPLWRPW 179
                  |.:||||
Mouse   212 TAARRAQSVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	21/55 (38%)
		ORANGE	81..125	CDD:128787	7/46 (15%)
Hes6	NP_062352.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		1/4 (25%)
		bHLH_SF	24..81	CDD:412148	21/59 (36%)
		Hairy_orange	96..134	CDD:400076	7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..209		14/62 (23%)
		WRPW motif	221..224		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700