Protein Alignment E(spl)m8-HLH and HES2

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 56/178 - (31%)
• Similarity: 86/178 - (48%)
• Gaps: 27/178 - (15%)

  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRG--DDGILRMDKAEMLESAVIFMRQQKTPKKVAQ 73
            :|..||:||::||||:|:.|..||.|:..|.|  :....:::||::||..|.|:  |:.|.....
Human    14 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFL--QELPASSWP 76

  Fly    74 EEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQN 138
            ....||.||::.||...|..::||:.:...:...:...::.||.|         .|.||
Human    77 TAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWR---------RAASA------ 126

  Fly   139 SMD-----CSSMDKAPLSPASSGYHSDCDSPAPSP--QPMQQPLWRPW 179
            ::|     .||...|| :||.:.......:|.|||  .|....|||||
Human   127 TLDGGRAGDSSGPSAP-APAPASAPEPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	24/59 (41%)
		ORANGE	81..125	CDD:128787	10/43 (23%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	24/61 (39%)
		ORANGE	84..127	CDD:128787	13/57 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		15/45 (33%)
		WRPW motif	170..173		2/2 (100%)