Protein Alignment E(spl)m8-HLH and hes1

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_001011194.1
• Gene: hes1 / 496617
• XenbaseID: XB-GENE-487995
• Length: 267
• Species: Xenopus tropicalis
• Alignment Length: 234
• Identity: 53/234 - (22%)
• Similarity: 88/234 - (37%)
• Gaps: 64/234 - (27%)

  Fly    10 YQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGI--LRMDKAEMLESAVIFMRQ-QKTPKKV 71
            ::|..||::|::||||:|:.|..||||:.:....|..  .:::||::||..|..:|. |:.....
 Frog    34 HRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTA 98

  Fly    72 AQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNL------------- 123
            |.......|..::.|:...:|||:|.:::..|::.|:...::.||......:
 Frog    99 ALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTDVRTRLLGHLANCMNQINAMNYPTQPQIPA 163

  Fly   124 ---------QQFHEAQSAADFIQNSMDCSSMDKAP-----------LSPASSGY----------- 157
                     |...:.|.||.....:.....|...|           |.||..|.
 Frog   164 AAAPHPAYGQPLVQLQGAAPQSSPAPIACKMGGPPVEAAKVYGGFQLVPAPDGQFAFLITNPAFP 228

  Fly   158 HSDCDSPA-----------PSPQPMQQP------LWRPW 179
            |:....|.           ||..|...|      :||||
 Frog   229 HNGSVIPVYTNSNVGTALPPSVSPSVMPSVTADSVWRPW 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	22/60 (37%)
		ORANGE	81..125	CDD:128787	9/65 (14%)
hes1	NP_001011194.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	22/60 (37%)
		Hairy_orange	109..148	CDD:462193	9/38 (24%)
		WRPW motif. /evidence=ECO:0000255	264..267		2/2 (100%)