DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and hes4

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_988870.1	Gene:	hes4 / 394465	XenbaseID:	XB-GENE-487830	Length:	281	Species:	Xenopus tropicalis

Alignment Length:	170	Identity:	45/170 - (26%)
Similarity:	78/170 - (45%)	Gaps:	32/170 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGI--LRMDKAEMLESAVIFMRQ-QKTPKKV 71
            ::|..||::|::||||:|:.|..||||:.:....|..  .:::||::||..|..:|. |:.....
Frog    34 HRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTA 98

  Fly    72 AQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGR-----VYKNLQQFHEAQS 131
            |.......|..::.|:...:|||:|.:::..|::.::...::.||..     |..|.||...:|.
Frog    99 ALTADPSVLGKYRAGFNECMNEVTRFLSTCEGVNTEVRTRLLGHLSSCLGQIVAMNYQQPPSSQQ 163

  Fly   132 AADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPM 171
                             ||       |....|..|:|.||
Frog   164 -----------------PL-------HVQLPSSTPAPVPM 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	22/59 (37%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	10/48 (21%)
hes4	NP_988870.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		3/9 (33%)
		bHLH-O_HES1_4	33..95	CDD:381465	22/60 (37%)
		Hairy_orange	110..147	CDD:369405	8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..281
		WRPW motif. /evidence=ECO:0000255	278..281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010