Protein Alignment E(spl)m8-HLH and HELT

DIOPT Version :9

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_001287710.1
• Gene: HELT / 391723
• HGNCID: 33783
• Length: 242
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 48/220 - (21%)
• Similarity: 79/220 - (35%)
• Gaps: 65/220 - (29%)

  Fly     6 KTQIYQKVKKPMLERQRRARMNKCLDNL-KTL-VAELRGDDGILRMDKAEMLESAVIFMRQQKTP 68
            :|.:..||    :|::||.|:|:||:.| ||: :|..:...|  :::|||:||..|.::|...:.
Human    10 RTPVSHKV----IEKRRRDRINRCLNELGKTVPMALAKQSSG--KLEKAEILEMTVQYLRALHSA 68

  Fly    69 KKVAQEEQSLPLDSFKN----GYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQ----- 124
            ......|::..|..|.|    ||...:..:...:.:...|     ::..|...|:...||
Human    69 DFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERM-----ETKDTKYARILAFLQSKARL 128

  Fly   125 -------------------QFHEAQSAADFIQNSMDCSSMDKAPLSPASSG-------------- 156
                               |.|.|  ..:|..:     |..:|.:.|..||
Human   129 GAEPAFPPLGSLPEPDFSYQLHPA--GPEFAGH-----SPGEAAVFPQGSGAGPFPWPPGAARSP 186

  Fly   157 ---YHSDCDSPAPSPQPMQQPLWRP 178
               |......|..||.....|...|
Human   187 ALPYLPSAPVPLASPAQQHSPFLTP 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	21/58 (36%)
		ORANGE	81..125	CDD:128787	9/71 (13%)
HELT	NP_001287710.1	bHLH-O_HELT	14..69	CDD:381414	21/60 (35%)
		Hairy_orange	87..127	CDD:400076	7/44 (16%)
		PRK14951	<133..>207	CDD:237865	13/80 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740