Protein Alignment E(spl)m8-HLH and HES3

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 48/213 - (22%)
• Similarity: 81/213 - (38%)
• Gaps: 86/213 - (40%)

  Fly    18 LERQRRARMNKCLDNLKTLVA-----ELRGDDGILRMDKAEMLESAVIFMR------QQKTPKKV 71
            :|::||||:|..|:.||:|:.     ::|.    .:::||::||.:|.:||      |...|...
Human     1 MEKKRRARINVSLEQLKSLLEKHYSHQIRK----RKLEKADILELSVKYMRSLQNSLQGLWPVPR 61

  Fly    72 AQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFI 136
            ..|:.|        |:.:.:..||:::.    ...::|..:...|           ..:|||.
Human    62 GAEQPS--------GFRSCLPGVSQLLR----RGDEVGSGLRCPL-----------VPESAAG-- 101

  Fly   137 QNSMDCSSMDKAPL------------------SPASSGYHS------------DCDSPAPSPQP- 170
                  |:||.|.|                  :||:.|..|            ...:..|.|||
Human   102 ------STMDSAGLGQEAPALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPA 160

  Fly   171 ----MQQP-----LWRPW 179
                .:.|     :||||
Human   161 SSRCAESPGLGLRVWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	20/62 (32%)
		ORANGE	81..125	CDD:128787	5/43 (12%)
HES3	NP_001019769.1	bHLH-O_HES3	1..55	CDD:381503	18/57 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		13/51 (25%)
		WRPW motif	175..178		2/2 (100%)