DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and heyl

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_859425.1	Gene:	heyl / 335134	ZFINID:	ZDB-GENE-030131-7074	Length:	310	Species:	Danio rerio

Alignment Length:	170	Identity:	41/170 - (24%)
Similarity:	75/170 - (44%)	Gaps:	16/170 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMR-QQKT 67
            :|...:.:|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..:: ....
Zfish    37 STSQILARKKRRGIIEKRRRDRINHSLSELRRLVPSAFEKQGSSKLEKAEILQMTVDHLKLLHAM 101

  Fly    68 PKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQFHEAQ 130
            ..|...:.::|.:|....|:...|.||.|.::|..|:  |..:|..:::||......|....::.
Zfish   102 GGKGYFDARALAVDYRTLGFRECVGEVVRYLSSLEGVESSDPIGARLVSHLSHCASELDPLLQSP 166

  Fly   131 SAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQP 170
            :|..|             |..|.:|.......||..|..|
Zfish   167 AALPF-------------PPWPWASFPQLQAASPPASSTP 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	16/57 (28%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	13/45 (29%)
heyl	NP_859425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HLH	44..101	CDD:238036	16/56 (29%)
		ORANGE	115..159	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740