DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and HEYL

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_055386.2	Gene:	HEYL / 26508	HGNCID:	4882	Length:	328	Species:	Homo sapiens

Alignment Length:	171	Identity:	40/171 - (23%)
Similarity:	72/171 - (42%)	Gaps:	39/171 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ-QKTPKKVAQE 74
            :|..:.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::. ..|......:
Human    44 RKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFD 108

  Fly    75 EQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQNS 139
            .::|.:|....|:...:.||.|.:....|.|                         |.||.::..
Human   109 ARALAVDFRSIGFRECLTEVIRYLGVLEGPS-------------------------SRADPVRIR 148

  Fly   140 MDCSSMDKAPLSPASSGYHSDCDSPAPSPQ-PMQQPLWRPW 179
            :         ||..:| |.::.: |:|:|. |:..|.| ||
Human   149 L---------LSHLNS-YAAEME-PSPTPTGPLAFPAW-PW 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	16/56 (29%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	7/43 (16%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		3/12 (25%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		17/66 (26%)
		HLH	42..100	CDD:238036	16/55 (29%)
		ORANGE	115..162	CDD:128787	14/82 (17%)
		Atrophin-1	<136..311	CDD:331285	17/79 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740