DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and HEY2

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_036391.1	Gene:	HEY2 / 23493	HGNCID:	4881	Length:	337	Species:	Homo sapiens

Alignment Length:	174	Identity:	48/174 - (27%)
Similarity:	83/174 - (47%)	Gaps:	22/174 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ-QK 66
            ||.:||. :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::. |.
Human    41 TTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQA 105

  Fly    67 TPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQFHEA 129
            |..|...:..:|.:|....|:...:.||:|.::|..|:  |..|...:::||...        ..
Human   106 TGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTC--------AT 162

  Fly   130 QSAADFIQNSMDCSSMDKAPLSP---ASSGYHSDCDSPAPSPQP 170
            |..|..:.:||   :....||.|   |::.:|    .||...||
Human   163 QREAAAMTSSM---AHHHHPLHPHHWAAAFHH----LPAALLQP 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	17/58 (29%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	11/45 (24%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		5/10 (50%)
		bHLH-O_HEY2	40..121	CDD:381490	24/79 (30%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		19/68 (28%)
		ORANGE	119..165	CDD:128787	12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..337
		YRPW motif	327..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740