Protein Alignment E(spl)m8-HLH and Helt

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: XP_006509452.1
• Gene: Helt / 234219
• MGIID: 3040955
• Length: 241
• Species: Mus musculus
• Alignment Length: 216
• Identity: 50/216 - (23%)
• Similarity: 80/216 - (37%)
• Gaps: 58/216 - (26%)

  Fly     6 KTQIYQKVKKPMLERQRRARMNKCLDNL-KTL-VAELRGDDGILRMDKAEMLESAVIFMRQQKTP 68
            :|.:..||    :|::||.|:|:||:.| ||: :|..:...|  :::|||:||..|.::|...:.
Mouse    10 RTPVSHKV----IEKRRRDRINRCLNELGKTVPMALAKQSSG--KLEKAEILEMTVQYLRALHSA 68

  Fly    69 KKVAQEEQSLPLDSFKN----GYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQ----- 124
            ......|::..|..|.|    ||...:..:...:.:...|     ::..|...|:...||
Mouse    69 DFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERM-----ETKDTKYARILAFLQSKARL 128

  Fly   125 ------------------QFHEAQ---------SAADFIQNSMDCS-----SMDKAPLSPASSGY 157
                              |.|.|.         .|..|.|.:...|     ...::|..|    |
Mouse   129 GAEPTFPPLSLPEPDFSYQLHAASPEFPGHSPGEATMFPQGATPGSFPWPPGAARSPALP----Y 189

  Fly   158 HSDCDSPAPSPQPMQQPLWRP 178
            .|....|.|||.....|...|
Mouse   190 LSSATVPLPSPAQQHSPFLAP 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	21/59 (36%)
		ORANGE	81..125	CDD:128787	9/70 (13%)
Helt	XP_006509452.1	bHLH-O_HELT	14..69	CDD:381414	21/60 (35%)
		Hairy_orange	86..127	CDD:462193	7/45 (16%)
		PLN02983	<147..>213	CDD:215533	17/68 (25%)