DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and Hey2

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_569101.1	Gene:	Hey2 / 155430	RGDID:	621405	Length:	339	Species:	Rattus norvegicus

Alignment Length:	159	Identity:	40/159 - (25%)
Similarity:	73/159 - (45%)	Gaps:	27/159 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQ-QK 66
            ||.:||. :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::. |.
  Rat    41 TTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQA 105

  Fly    67 TPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKNLQQFHEA 129
            |..|...:..:|..|....|:...:.||:|.::|..|:  |..|...:::||.
  Rat   106 TGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLS------------ 158

  Fly   130 QSAADFIQNSMDCSSMDKAPLSPASSGYH 158
                       .|:|..:|.:..:|..:|
  Rat   159 -----------TCASQREAAVMTSSMSHH 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	17/58 (29%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	11/45 (24%)
Hey2	NP_569101.1	HLH	49..105	CDD:238036	16/55 (29%)
Hey2	NP_569101.1	ORANGE	120..165	CDD:128787	13/67 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740