Protein Alignment E(spl)m8-HLH and Hes1

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Alignment Length: 166
• Identity: 44/166 - (26%)
• Similarity: 79/166 - (47%)
• Gaps: 14/166 - (8%)

  Fly    10 YQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGI--LRMDKAEMLESAVIFMRQ-QKTPKKV 71
            ::|..||::|::||||:|:.|..||||:.:....|..  .:::||::||..|..:|. |:.....
Mouse    34 HRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTA 98

  Fly    72 AQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFI 136
            |.......|..::.|:...:|||:|.:::..|::.::...::.||......:........|...:
Mouse    99 ALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPAL 163

  Fly   137 QNSMDCSSMDKAPLSPASSGYHSDCDSP-APSPQPM 171
            |          ||..|..||......:| ||.|.|:
Mouse   164 Q----------APPPPPPSGPAGPQHAPFAPPPPPL 189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	22/60 (37%)
		ORANGE	81..125	CDD:128787	8/43 (19%)
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		3/9 (33%)
		bHLH-O_HES1_4	33..95	CDD:381465	22/60 (37%)
		Hairy_orange	109..148	CDD:462193	8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		12/42 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282
		WRPW motif	277..280