DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and hes5.5

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_001165751.1	Gene:	hes5.5 / 100337645	XenbaseID:	XB-GENE-6492485	Length:	158	Species:	Xenopus tropicalis

Alignment Length:	180	Identity:	50/180 - (27%)
Similarity:	80/180 - (44%)	Gaps:	37/180 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EYTTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGIL--RMDKAEMLESAVIFMRQ 64
            |:..|.|..:|::||::|:.||.|:|..::.|:.|: |...|...|  :.:||::||.||.||:|
Frog    13 EHNHKAQGIRKMRKPVVEKMRRDRINSSIEQLRMLL-EKEFDSHHLPSKPEKADILEVAVSFMQQ 76

  Fly    65 QKTPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEA 129
            |...|  .::..|.|.   ..||...:.:....:            |:..|.....|.:|.|||.
Frog    77 QMATK--CKQSSSAPQ---MEGYSKCLQDSLHFL------------SLQKHAELHRKVIQNFHEN 124

  Fly   130 QSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW 179
            .|.:..:     |.|:         |.|:   .:|.....|..:.|||||
Frog   125 HSLSQGL-----CRSV---------SPYY---QTPTIGTAPPAKLLWRPW 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	23/58 (40%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	5/43 (12%)
hes5.5	NP_001165751.1	bHLH-O_HES5	23..77	CDD:381467	21/54 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010