DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and hes5.3

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	XP_002933894.1	Gene:	hes5.3 / 100101782	XenbaseID:	XB-GENE-480450	Length:	160	Species:	Xenopus tropicalis

Alignment Length:	186	Identity:	48/186 - (25%)
Similarity:	77/186 - (41%)	Gaps:	55/186 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAE----LRGDDGILRMDKAEMLESAVIFMRQ 64
            |||.:  .|::|||:|:.||.|:|..::.|:.|:.:    |:.|.   :.:||::||.||.|::|
Frog    20 TTKQK--NKIRKPMVEKMRRDRINSSINQLQNLLEKEFQLLQPDS---KPEKADILELAVKFLKQ 79

  Fly    65 Q-----KTPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQ 124
            |     |..:|..|:        |..||.|.::|....::
Frog    80 QICSQSKNNRKDYQD--------FSQGYSNCLHETFAFLS------------------------- 111

  Fly   125 QFHEAQSAADF-IQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW 179
             ||..:..... :.|...|  :|..|...:.|..|    ...|.|....:.|||||
Frog   112 -FHRTEEEMQLKLMNHFQC--LDSQPRGISVSSSH----QKGPGPVASTKILWRPW 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	22/65 (34%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	5/43 (12%)
hes5.3	XP_002933894.1	bHLH-O_HES5	26..84	CDD:381467	22/60 (37%)
hes5.3	XP_002933894.1	Hairy_orange	93..135	CDD:383064	11/77 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010