Protein Alignment E(spl)m7-HLH and BHLHE40

DIOPT Version :9

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 55/207 - (26%)
• Similarity: 86/207 - (41%)
• Gaps: 45/207 - (21%)

  Fly     6 EMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKE 70
            :..:||   |:...|:|:|||.|||:|:.:||||:.|.:..|.....|||.:||:|::|::.|..
Human    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTN 109

  Fly    71 ---------------------SKKHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMT 114
                                 |.::|....|. |.:|:...|.||.:.||..........:.|:|
Human   110 LIDQQQQKIIALQSGLQAGELSGRNVETGQEM-FCSGFQTCAREVLQYLAKHENTRDLKSSQLVT 173

  Fly   115 HLGMRLNQLEQ------PMEQPQAV----NTPLSIVCGSSSSSS----------TYSSASSCSSI 159
            ||...:::|.|      |.:....|    ..|.|...||.....          .:||.....|.
Human   174 HLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSD 238

  Fly   160 SPVSSGYASDNE 171
            :...|||..::|
Human   239 TDTDSGYGGESE 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/80 (31%)
		ORANGE	81..125	CDD:128787	12/43 (28%)
BHLHE40	NP_003661.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer	1..139		28/93 (30%)
		bHLH-O_DEC1	40..129	CDD:381592	26/83 (31%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		15/69 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840