DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and Bhlhe40

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_445780.2	Gene:	Bhlhe40 / 79431	RGDID:	68439	Length:	411	Species:	Rattus norvegicus

Alignment Length:	207	Identity:	55/207 - (26%)
Similarity:	90/207 - (43%)	Gaps:	45/207 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKE 70
            :..:||   |:...|:|:|||.|||:|:.:||||:.|.:..|.....|||.:||:|::|::.|..
  Rat    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTN 109

  Fly    71 ---------------------SKKHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMT 114
                                 |.:::.|..|. |.:|:...|.||.:.||..........:.|:|
  Rat   110 LIDQQQQKIMALQSGLQAGDLSGRNIEAGQEM-FCSGFQTCAREVLQYLAKHENTRDLKSSQLVT 173

  Fly   115 HLGMRLNQLEQ------PMEQ-PQAVN---TPLSIVCGSSSSSS--------TY--SSASSCSSI 159
            ||...:::|.|      |::. |:.|:   .|..:..||.....        |:  |......|.
  Rat   174 HLHRVVSELLQGSASRKPLDSAPKPVDFKEKPSFLAKGSEGPGKNCVPVIQRTFAPSGGEQSGSD 238

  Fly   160 SPVSSGYASDNE 171
            :...|||..:.|
  Rat   239 TDTDSGYGGELE 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/80 (31%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	12/43 (28%)
Bhlhe40	NP_445780.2	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		28/93 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		bHLH-O_DEC1	40..129	CDD:381592	26/83 (31%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	13/44 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..293		13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840