DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and her4.3

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_001154880.1	Gene:	her4.3 / 792198	ZFINID:	ZDB-GENE-081030-7	Length:	152	Species:	Danio rerio

Alignment Length:	183	Identity:	53/183 - (28%)
Similarity:	83/183 - (45%)	Gaps:	48/183 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KTYQYRKVMKPLLERKRRARINKCLDELKDLMA-ECVAQTGDAKFEKADILEVTVQHLRKLKESK 72
            :|....|:.||::|:.||.|||..:::||.|:| |.:.|..|::.|||||||:|:..||:   |:
Zfish    13 ETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFIKQQPDSRQEKADILEMTLDFLRR---SQ 74

  Fly    73 KHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQL----EQPMEQPQAV 133
            |...|...:|      |...|....|:..|         :.|....||.:|    :.|.:|...|
Zfish    75 KSSAAGDGRS------RCVQEAVSFLSQCP---------VQTQSHTRLMKLFLHMQTPADQHTRV 124

  Fly   134 NTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQISSPGQVWRPW 186
            :.|        .::.|::: ||....:||.|                .:||||
Zfish   125 DNP--------QTTETHAN-SSAKQHTPVRS----------------HIWRPW 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	27/60 (45%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	9/47 (19%)
her4.3	NP_001154880.1	HLH	19..75	CDD:238036	27/58 (47%)
her4.3	NP_001154880.1	ORANGE	77..123	CDD:128787	12/60 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840