DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and hey2

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_571697.2	Gene:	hey2 / 58146	ZFINID:	ZDB-GENE-000526-1	Length:	324	Species:	Danio rerio

Alignment Length:	281	Identity:	66/281 - (23%)
Similarity:	98/281 - (34%)	Gaps:	120/281 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKES--KKHVP 76
            ||..:.::|::||.|||..|.||:.|:.....:.|.||.|||:||::||.||:.|:.:  |.:..
Zfish    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFD 113

  Fly    77 ANP-EQSFRA-GYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE------------- 124
            |:. ...|.: |:.....||:|.|:|:..:|.:  ....|::||....:|.|
Zfish   114 AHSLAMDFLSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQREAAAMTTSIAHHQQ 178

  Fly   125 -----------QPM---------------------EQPQ-------------------------- 131
                       .|:                     |.||
Zfish   179 ALHPHHWAAALHPIPAAFLQQSGLPSSESSSGRLSEAPQRGAALFSHSDSALRAPSTGSVAPCVP 243

  Fly   132 ---------------------AVNTPLSIVCG----------SSSSSSTYSSASSCSSISPVSSG 165
                                 |...|||...|          ||.:|||.||:.|.|:.|..|||
Zfish   244 PLSTSLLSLSATVHAAAAAAAAQTFPLSFPAGFPLFSPSVTASSVASSTVSSSVSTSTTSQQSSG 308

  Fly   166 YASDNESLLQISSPGQVWRPW 186
                        |..:.:|||
Zfish   309 ------------SSSKPYRPW 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/60 (42%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	13/70 (19%)
hey2	NP_571697.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		HLH	49..105	CDD:238036	25/55 (45%)
		Hairy_orange	125..162	CDD:284859	10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..324		12/36 (33%)
		YRPW motif	314..317		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740