Protein Alignment E(spl)m7-HLH and HES4

DIOPT Version :10

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 56/185 - (30%)
• Similarity: 89/185 - (48%)
• Gaps: 20/185 - (10%)

  Fly    18 KPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKLK--ESKKHVPAN 78
            ||::|::||||||:.|.:||.|:.:.:.:...  :|.|||||||:||:|||.|:  :....:.|:
Human    65 KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSAD 129

  Fly    79 PE--QSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQPMEQPQAVNTPLSIVC 141
            |.  ..:|||:.....||:|.||....|.....:.|:.||...|.|| .|..:|.:::....
Human   130 PAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQL-GPSRRPASLSPAAP--- 190

  Fly   142 GSSSSSSTYSSASSCSSIS--------PVSSGYASDNESLLQI--SSPGQVWRPW 186
            ..:.:...|:......|:.        |:..|......:..:.  ..||..||||
Human   191 AEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPW 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	27/58 (47%)
		ORANGE	81..125	CDD:128787	15/43 (35%)
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	27/55 (49%)
		Hairy_orange	135..174	CDD:462193	12/38 (32%)