Protein Alignment E(spl)m7-HLH and Hes6

DIOPT Version :10

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_062352.1
• Gene: Hes6 / 55927
• MGIID: 1859852
• Length: 224
• Species: Mus musculus
• Alignment Length: 203
• Identity: 63/203 - (31%)
• Similarity: 91/203 - (44%)
• Gaps: 34/203 - (16%)

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQH----LRKLKESKKH 74
            ||..|||:|:|||||||:.|.||:.|:|....|   ||.|.|::||:||:.    ||.....::.
Mouse    26 RKARKPLVEKKRRARINESLQELRLLLAGTEVQ---AKLENAEVLELTVRRVQGALRGRAREREQ 87

  Fly    75 VPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQPMEQPQAVNTPLSI 139
            :.|...:.|.||||:..:||...:::...:|......|:.|| :....|.:.......:...|:.
Mouse    88 LQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHL-LESMPLREGSSFQDLLGDSLAG 151

  Fly   140 VCGSSSSSSTYSSASSCSSI-SPVSSG--YASDNESL--------------LQISSPG------- 180
            :.|.|..||.....|..|.: ||...|  ..||.|.:              |..:|.|
Mouse   152 LPGGSGRSSWPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVSTSLGSLTAARR 216

  Fly   181 --QVWRPW 186
              .|||||
Mouse   217 AQSVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	29/62 (47%)
		ORANGE	81..125	CDD:128787	12/43 (28%)
Hes6	NP_062352.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		2/4 (50%)
		bHLH_SF	24..81	CDD:469605	29/57 (51%)
		Hairy_orange	95..134	CDD:462193	11/39 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..209		15/62 (24%)
		WRPW motif	221..224		2/2 (100%)