DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and HES2

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_061962.2	Gene:	HES2 / 54626	HGNCID:	16005	Length:	173	Species:	Homo sapiens

Alignment Length:	178	Identity:	56/178 - (31%)
Similarity:	85/178 - (47%)	Gaps:	19/178 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKLKESKKH 74
            :.||.:|||||::||||||:.|.:||.|:...:.:...  :|.||||:||:||:.|::|..|...
Human    12 ELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWP 76

  Fly    75 VPAN-PEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQPMEQPQAVNTPLS 138
            ..|. |..|:|.||......::|.|.:...::.|....|:.||..|            |.:..|.
Human    77 TAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRR------------AASATLD 129

  Fly   139 IVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQISSPGQVWRPW 186
            ......||..:..:.:..|:..|.|:...|...   ....|| :||||
Human   130 GGRAGDSSGPSAPAPAPASAPEPASAPVPSPPS---PPCGPG-LWRPW 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	29/61 (48%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	11/43 (26%)
HES2	NP_061962.2	HLH	12..70	CDD:238036	27/57 (47%)
		ORANGE	84..127	CDD:128787	12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..173		11/48 (23%)
		WRPW motif	170..173		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840