DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(spl)m7-HLH and helt

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_996948.1	Gene:	helt / 404275	ZFINID:	ZDB-GENE-040824-6	Length:	270	Species:	Danio rerio

Alignment Length:	193	Identity:	59/193 - (30%)
Similarity:	83/193 - (43%)	Gaps:	40/193 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YEM--SKTYQYRK--VMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHL 65
            |||  ||....:|  |...::|::||.|||:||:||...:...:|:....|.|||:|||:|||:|
Zfish    47 YEMMASKMKDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQNSGKLEKAEILEMTVQYL 111

  Fly    66 RKLKESKKHVPANPEQS---------FRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLN 121
            |.|..:  ..|...|:.         |..||......:...|.::.|::     |..|.....|.
Zfish   112 RALHSA--DFPRGREKGELLTEFANYFHYGYHECMKNLVHYLTTVERME-----TKDTKYARILA 169

  Fly   122 QLEQPMEQPQAVNTPLSIVCGSSSSSSTYSSASSC----SSISPVSSGYASDNESLLQISSPG 180
            .|     |.:.|..|   |.||..:.|...:...|    .|.||        .||:.|.|.||
Zfish   170 FL-----QSKVVTEP---VFGSLGTISPDPTDLLCQLEYQSPSP--------TESVFQQSPPG 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	26/61 (43%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	9/52 (17%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		HLH	62..115	CDD:278439	24/52 (46%)
		Hairy_orange	136..173	CDD:284859	9/46 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740