Protein Alignment E(spl)m7-HLH and HES3

DIOPT Version :9

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 189
• Identity: 62/189 - (32%)
• Similarity: 86/189 - (45%)
• Gaps: 34/189 - (17%)

  Fly    21 LERKRRARINKCLDELKDLMAECVA-QTGDAKFEKADILEVTVQHLRKLKESKK---HVPANPEQ 81
            :|:|||||||..|::||.|:.:..: |....|.|||||||::|:::|.|:.|.:   .||...||
Human     1 MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPRGAEQ 65

  Fly    82 --SFR------AGYIRAANEVSRALASLPRVDVAFGTTL-MTHLGMRLNQLEQPMEQPQAVNTPL 137
              .||      :..:|..:||...|......:.|.|:|: ...||.....|.:|.  ..||..|.
Human    66 PSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAPALFRPC--TPAVWAPA 128

  Fly   138 SIVCGSSS-------SSSTYSSASSCSSISPVSSGYASDNESLLQISSPG---QVWRPW 186
            ....|..|       ..|...|::|.....|.||..|         .|||   :|||||
Human   129 PAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCA---------ESPGLGLRVWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/52 (48%)
		ORANGE	81..125	CDD:128787	13/52 (25%)
HES3	NP_001019769.1	HLH	1..54	CDD:238036	25/52 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		17/60 (28%)
		WRPW motif	175..178		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840