DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and heyl

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_859425.1	Gene:	heyl / 335134	ZFINID:	ZDB-GENE-030131-7074	Length:	310	Species:	Danio rerio

Alignment Length:	189	Identity:	54/189 - (28%)
Similarity:	92/189 - (48%)	Gaps:	17/189 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKE--SKKHVP 76
            ||..:.::|::||.|||..|.||:.|:.....:.|.:|.|||:||::||.||:.|..  .|.:..
Zfish    44 RKKRRGIIEKRRRDRINHSLSELRRLVPSAFEKQGSSKLEKAEILQMTVDHLKLLHAMGGKGYFD 108

  Fly    77 ANP-EQSFRA-GYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLEQPMEQPQAVNTP- 136
            |.. ...:|. |:.....||.|.|:||..|:.:  .|..|::||....::|:..::.|.|:..|
Zfish   109 ARALAVDYRTLGFRECVGEVVRYLSSLEGVESSDPIGARLVSHLSHCASELDPLLQSPAALPFPP 173

  Fly   137 ------LSIVCGSSSSSSTYSSASSCSSISPVSS----GYASDNESLLQISSPGQVWRP 185
                  ..:...|..:|||....::...::|..:    ||.|....:..:|:.|.:..|
Zfish   174 WPWASFPQLQAASPPASSTPFPPNARRDLTPHGTATILGYPSPALRMGSLSTQGTILNP 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	24/60 (40%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	14/46 (30%)
heyl	NP_859425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HLH	44..101	CDD:238036	24/56 (43%)
		ORANGE	115..159	CDD:128787	13/43 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740