Protein Alignment E(spl)m7-HLH and HES1

DIOPT Version :9

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 64/256 - (25%)
• Similarity: 102/256 - (39%)
• Gaps: 91/256 - (35%)

  Fly    12 QYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKLKESKKH 74
            ::||..||::|::||||||:.|.:||.|:.:.:.:...  :|.|||||||:||:|||.|:.::..
Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    75 VPANPEQS----FRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQ---------- 125
            ...:.:.|    :|||:....|||:|.|::...|:....|.|:.||...:.|:..
Human    98 AALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPA 162

  Fly   126 -------------PMEQPQAVNTPLSIVCGSSSSS------------------------------ 147
                         |...|.|...||..:.|.::..
Human   163 LQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDG 227

  Fly   148 ------------------STYSSASSCS----SISPVSSGYASDNESLLQISSPGQVWRPW 186
                              ..|:|.|..|    ::|| |||.:...:|:         ||||
Human   228 QFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSP-SSGPSLTADSM---------WRPW 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	29/61 (48%)
		ORANGE	81..125	CDD:128787	15/47 (32%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	29/61 (48%)
		Hairy_orange	110..148	CDD:400076	13/37 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		6/42 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		11/35 (31%)
		WRPW motif	275..278		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840