DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and Hes1

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus

Alignment Length:	257	Identity:	67/257 - (26%)
Similarity:	104/257 - (40%)	Gaps:	92/257 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKLKESKKH 74
            ::||..||::|::||||||:.|.:||.|:.:.:.:...  :|.|||||||:||:|||.|:.::..
  Rat    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    75 VPANPEQS----FRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQ---------- 125
            ...:.:.|    :|||:....|||:|.|::...|:....|.|:.||...:.|:..
  Rat    98 AALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPA 162

  Fly   126 --------------PMEQPQAVNTPL------------SIVC--GSSSSSS-------------- 148
                          |...|.|...||            |..|  ||.:..:
  Rat   163 LQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPD 227

  Fly   149 --------------------TYSSASSCS----SISPVSSGYASDNESLLQISSPGQVWRPW 186
                                .|:|.|..|    ::|| |||.:...:|:         ||||
  Rat   228 GQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSP-SSGSSLTADSM---------WRPW 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	29/61 (48%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	15/47 (32%)
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	29/61 (48%)
		Hairy_orange	110..148	CDD:400076	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281		11/35 (31%)
		WRPW motif	276..279		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840