DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and Hes2

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_062109.1	Gene:	Hes2 / 29567	RGDID:	62082	Length:	157	Species:	Rattus norvegicus

Alignment Length:	179	Identity:	57/179 - (31%)
Similarity:	83/179 - (46%)	Gaps:	37/179 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QYRKVMKPLLERKRRARINKCLDELKDLMAECV-AQTGD-AKFEKADILEVTVQHLRKLKES--K 72
            :.||.:|||||::||||||:.|.:||.|:...: |:|.. :|.|||||||:||:.||:...|  .
  Rat    12 ELRKSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCS 76

  Fly    73 KHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQPMEQPQAVNTPL 137
            ...|.:.: |:..||......::|.|.:...::.|....|:.||..|
  Rat    77 TEAPGSLD-SYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQR------------------ 122

  Fly   138 SIVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQISSPGQVWRPW 186
              .......|.|.:|||:.:...||...           ||.| :||||
  Rat   123 --TVSGGPPSLTPASASAPAPSPPVPPP-----------SSLG-LWRPW 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	32/63 (51%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	10/43 (23%)
Hes2	NP_062109.1	HLH	12..69	CDD:238036	30/56 (54%)
		ORANGE	84..128	CDD:128787	10/64 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		12/44 (27%)
		WRPW motif	154..157		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840