DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and Hes7

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	XP_038941367.1	Gene:	Hes7 / 287423	RGDID:	1305914	Length:	358	Species:	Rattus norvegicus

Alignment Length:	168	Identity:	51/168 - (30%)
Similarity:	77/168 - (45%)	Gaps:	36/168 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KVMKPLLERKRRARINKCLDELKDLMAECVAQTGD-----AKFEKADILEVTVQHLRKLKESKKH 74
            :::|||:|::||.|||:.|:||:.|:.|   :|.|     .|.|||:|||..|.:||  :.|:..
  Rat    43 EMLKPLVEKRRRDRINRSLEELRLLLLE---RTRDQNLRNPKLEKAEILEFAVGYLR--ERSRVE 102

  Fly    75 VPANPE-------------QSFRAGYIRAANEVSRALASLPRV--DVAFGTTLMTHLGMRLNQLE 124
            .|....             ::.|||. .|.:||.|.:...|.|  |....|.....|.:
  Rat   103 PPGTARGVGQRREAGGWGARNARAGE-GAGSEVDRGVGERPAVLPDEVNNTRACLSLCL------ 160

  Fly   125 QPMEQPQAVNTPLSIVCGSSSSSSTYSSASSCSSISPV 162
             |...|..|: |.|.:|..:..:|.  |.....|::||
  Rat   161 -PRCPPLHVH-PASCLCLCARLTSV--SLRPAPSLNPV 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	27/62 (44%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	12/45 (27%)
Hes7	XP_038941367.1	bHLH-O_HES7	44..102	CDD:381468	27/62 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740