Protein Alignment E(spl)m7-HLH and HEYL

DIOPT Version :10

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_055386.2
• Gene: HEYL / 26508
• HGNCID: 4882
• Length: 328
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 52/185 - (28%)
• Similarity: 78/185 - (42%)
• Gaps: 33/185 - (17%)

  Fly     8 SKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKESK 72
            |...|.||..:.::|::||.|||..|.||:.|:.....:.|.:|.|||::|::||.||:.|
Human    38 SSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKML---- 98

  Fly    73 KHVPANP--------EQSFRA-GYIRAANEVSRALASL----PRVDVAFGTTLMTHLGMRLNQLE 124
             |.....        ...||: |:.....||.|.|..|    .|.| .....|::|    ||...
Human    99 -HATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRAD-PVRIRLLSH----LNSYA 157

  Fly   125 QPMEQPQAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQISSP 179
            ..||.......||:.      .:..:|...||..:..:|:..|    .|.::.||
Human   158 AEMEPSPTPTGPLAF------PAWPWSFFHSCPGLPALSNQLA----ILGRVPSP 202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	25/64 (39%)
		ORANGE	81..125	CDD:128787	14/48 (29%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		6/18 (33%)
		bHLH-O_HEYL	36..109	CDD:381453	26/75 (35%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		25/73 (34%)
		ORANGE	115..162	CDD:128787	15/51 (29%)
		PHA03247	<136..311	CDD:223021	18/82 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..308