DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m7-HLH and HEYL

DIOPT Version :9

Sequence 1:NP_536753.1 Gene:E(spl)m7-HLH / 43160 FlyBaseID:FBgn0002633 Length:186 Species:Drosophila melanogaster
Sequence 2:NP_055386.2 Gene:HEYL / 26508 HGNCID:4882 Length:328 Species:Homo sapiens


Alignment Length:188 Identity:52/188 - (27%)
Similarity:75/188 - (39%) Gaps:43/188 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKESK 72
            |...|.||..:.::|::||.|||..|.||:.|:.....:.|.:|.|||::|::||.||:.|    
Human    38 SSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKML---- 98

  Fly    73 KHVPANP--------EQSFRA-GYIRAANEVSRALASL----PRVDVAFGTTLMTHLGMRLNQLE 124
             |.....        ...||: |:.....||.|.|..|    .|.| .....|::|    ||...
Human    99 -HATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRAD-PVRIRLLSH----LNSYA 157

  Fly   125 QPMEQPQAVNTPLSIVCGSSSSSSTYSSASSCSSI--------------SPVSSGYAS 168
            ..||.......||:.      .:..:|...||..:              |||..|.:|
Human   158 AEMEPSPTPTGPLAF------PAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSS 209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m7-HLHNP_536753.1 HLH 13..73 CDD:238036 23/59 (39%)
ORANGE 81..125 CDD:128787 14/48 (29%)
HEYLNP_055386.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 6/18 (33%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 25/73 (34%)
HLH 42..100 CDD:238036 24/62 (39%)
ORANGE 115..162 CDD:128787 15/51 (29%)
Atrophin-1 <136..311 CDD:331285 18/85 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140923
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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