DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and HEY2

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_036391.1	Gene:	HEY2 / 23493	HGNCID:	4881	Length:	337	Species:	Homo sapiens

Alignment Length:	205	Identity:	58/205 - (28%)
Similarity:	90/205 - (43%)	Gaps:	43/205 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKES------K 72
            ||..:.::|::||.|||..|.||:.|:.....:.|.||.|||:||::||.||:.|:.:      .
Human    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFD 113

  Fly    73 KHVPANPEQSFRAGYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE----------- 124
            .|..|....|.  |:.....||:|.|:|:..:|.:  ....|::||.....|.|
Human   114 AHALAMDFMSI--GFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHH 176

  Fly   125 -QPMEQ----------PQAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYA------SDNES 172
             .|:..          |.|:..|    .|..:|.||....|:.|.:.| :.|.|      :..:|
Human   177 HHPLHPHHWAAAFHHLPAALLQP----NGLHASESTPCRLSTTSEVPP-AHGSALLTATFAHADS 236

  Fly   173 LLQISSPGQV 182
            .|::.|.|.|
Human   237 ALRMPSTGSV 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/64 (39%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	13/57 (23%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH-O_HEY2	40..121	CDD:381490	27/71 (38%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		25/66 (38%)
		ORANGE	119..165	CDD:128787	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..337
		YRPW motif	327..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740