Protein Alignment E(spl)m7-HLH and HEY1

DIOPT Version :9

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 61/252 - (24%)
• Similarity: 99/252 - (39%)
• Gaps: 79/252 - (31%)

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAEC----VAQTGDAKFEKADILEVTVQHLRKLKES--K 72
            ||..:.::|::||.|||..|.||:.|:...    |.:.|.||.|||:||::||.||:.|..:  |
Human    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGK 114

  Fly    73 KHVPANP-EQSFRA-GYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE--------- 124
            .:..|:. ...:|: |:.....||:|.|:.:..:|.:  ....|::||....:|.|
Human   115 GYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGL 179

  Fly   125 ----------------QPMEQPQ-----------------------------AVNTP-------- 136
                            .|:..||                             |:..|
Human   180 GHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV 244

  Fly   137 LSIVCGSSSSSSTYSSASSCSSISPVSSG-YASDNESLLQISSP------GQVWRPW 186
            |.:|..:|..|....|:.:..|..|.|.| :...:.:.|..|:|      |:.:|||
Human   245 LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPW 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	26/64 (41%)
		ORANGE	81..125	CDD:128787	12/71 (17%)
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		1/1 (100%)
		bHLH_SF	41..126	CDD:381792	28/75 (37%)
		ORANGE	124..170	CDD:128787	11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		4/37 (11%)
		YRPW motif	298..301		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740