Protein Alignment E(spl)m7-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 207
• Identity: 56/207 - (27%)
• Similarity: 91/207 - (43%)
• Gaps: 45/207 - (21%)

  Fly     6 EMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKE 70
            :..:||   |:...|:|:|||.|||:|:.:||||:.|.:..|.....|||.:||:|::|::.|..
Mouse    48 DSKETY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTN 109

  Fly    71 ---------------------SKKHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMT 114
                                 |.:::.|..|. |.:|:...|.||.:.||..........:.|:|
Mouse   110 LIDQQQQKIIALQSGLQAGDLSGRNLEAGQEM-FCSGFQTCAREVLQYLAKHENTRDLKSSQLVT 173

  Fly   115 HLGMRLNQLEQ------PMEQ-PQAVN---TPLSIVCGSSSSSS--------TY--SSASSCSSI 159
            ||...:::|.|      |::. |:||:   .|..:..||.....        |:  |......|.
Mouse   174 HLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFAPSGGEQSGSD 238

  Fly   160 SPVSSGYASDNE 171
            :...|||..:.|
Mouse   239 TDTDSGYGGELE 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	27/86 (31%)
		ORANGE	81..125	CDD:128787	12/43 (28%)
Bhlhe40	NP_035628.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		28/93 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	26/83 (31%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..294		6/24 (25%)