DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m7-HLH and Hey2

DIOPT Version :9

Sequence 1:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_038932.1	Gene:	Hey2 / 15214	MGIID:	1341884	Length:	339	Species:	Mus musculus

Alignment Length:	205	Identity:	57/205 - (27%)
Similarity:	92/205 - (44%)	Gaps:	43/205 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKES------K 72
            ||..:.::|::||.|||..|.||:.|:.....:.|.||.|||:||::||.||:.|:.:      .
Mouse    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFD 113

  Fly    73 KHVPANPEQSFRAGYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE----------- 124
            .|..|....|.  |:.....||:|.|:|:..:|.:  ....|::||....:|.|
Mouse   114 AHALATDFMSI--GFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHH 176

  Fly   125 -QPME----------------QPQAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYASDNES 172
             .|:.                ||..::|..|..|..|:||...|:..  |::...:..:|   :|
Mouse   177 HHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHG--SALLTATFAHA---DS 236

  Fly   173 LLQISSPGQV 182
            .|::.|.|.|
Mouse   237 ALRMPSGGTV 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/64 (39%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	13/57 (23%)
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269\|PubMed:11486045	47..116		25/66 (38%)
		HLH	49..105	CDD:238036	25/55 (45%)
		ORANGE	120..165	CDD:128787	12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..339
		YQPW motif	329..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740