Protein Alignment E(spl)m7-HLH and Hes1

DIOPT Version :10

• Sequence 1: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Sequence 2: NP_032261.1
• Gene: Hes1 / 15205
• MGIID: 104853
• Length: 282
• Species: Mus musculus
• Alignment Length: 258
• Identity: 67/258 - (25%)
• Similarity: 105/258 - (40%)
• Gaps: 93/258 - (36%)

  Fly    12 QYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKLKESKKH 74
            ::||..||::|::||||||:.|.:||.|:.:.:.:...  :|.|||||||:||:|||.|:.::..
Mouse    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    75 VPANPEQS----FRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQ------------- 122
            ...:.:.|    :|||:....|||:|.|::...|:....|.|:.||...:.|
Mouse    98 AALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPA 162

  Fly   123 LEQPMEQPQ------------------------AVNTPLSIVC--GSSSSSS------------- 148
            |:.|...|.                        |...|.|..|  ||.:..:
Mouse   163 LQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAP 227

  Fly   149 ---------------------TYSSASSCS----SISPVSSGYASDNESLLQISSPGQVWRPW 186
                                 .|:|.|..|    ::|| |||.:..::|:         ||||
Mouse   228 DGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSP-SSGSSLTSDSM---------WRPW 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	29/62 (47%)
		ORANGE	81..125	CDD:128787	16/60 (27%)
Hes1	NP_032261.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	29/61 (48%)
		Hairy_orange	109..148	CDD:462193	13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..204		6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..282		11/35 (31%)
		WRPW motif	277..280		2/2 (100%)