Protein Alignment E(spl)m5-HLH and HES7

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: XP_054173538.1
• Gene: HES7 / 84667
• HGNCID: 15977
• Length: 265
• Species: Homo sapiens
• Alignment Length: 221
• Identity: 48/221 - (21%)
• Similarity: 83/221 - (37%)
• Gaps: 67/221 - (30%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAIL--RMDKAEMLEAALVFMRKQ-------VV 75
            |:.|||:|::||.|:|:.|:.|:.|:.|...|..:.  :::|||:||.|:.::|::       ..
Human    49 KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPAAA 113

  Fly    76 KQQAPVSPL-PMDSFKNGYMNAVSE-ISRVMA----CTPAMSVDVGKTVMTHLGVEFQRMLQADQ 134
            ....|.||: ..::..:.|::...| :.|:.|    .:||....:...:..:|..:..|....|.
Human   114 APGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFSALHGYLRPKPPRPKPVDP 178

  Fly   135 VQTSVTTSTPRP-LSPASSG----------YHSDNEDSQSAASPK-------------------- 168
                 ....||| |.||:..          .|..:...:.|.||.
Human   179 -----RPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGAPAPLTGLLP 238

  Fly   169 ----------------PVEETMWRPW 178
                            |.....||||
Human   239 PPPPPHRQDGAPKAPLPPPPAFWRPW 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	21/66 (32%)
		ORANGE	87..131	CDD:128787	8/48 (17%)
HES7	XP_054173538.1	bHLH-O_HES7	48..108	CDD:381468	21/58 (36%)