Protein Alignment E(spl)m5-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_445780.2
• Gene: Bhlhe40 / 79431
• RGDID: 68439
• Length: 411
• Species: Rattus norvegicus
• Alignment Length: 171
• Identity: 36/171 - (21%)
• Similarity: 67/171 - (39%)
• Gaps: 43/171 - (25%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAALVFMR---KQVVKQQAPV 81
            |:...|:|::||.|:|:|:..||.|:.|......:..::||.:||..|..::   ..:.:||..:
  Rat    54 KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKI 118

  Fly    82 SPLP----------------MDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRML 130
            ..|.                .:.|.:|:.....|:.:.:|............::|||......:|
  Rat   119 MALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELL 183

  Fly   131 QADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVE 171
            |.        :::.:||..|                ||||:
  Rat   184 QG--------SASRKPLDSA----------------PKPVD 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	17/60 (28%)
		ORANGE	87..131	CDD:128787	7/43 (16%)
Bhlhe40	NP_445780.2	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		20/84 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		bHLH-O_DEC1	40..129	CDD:381592	20/74 (27%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..293		7/31 (23%)