DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and Bhlhe41

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_077789.1	Gene:	Bhlhe41 / 79362	MGIID:	1930704	Length:	410	Species:	Mus musculus

Alignment Length:	200	Identity:	43/200 - (21%)
Similarity:	81/200 - (40%)	Gaps:	59/200 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 STTFVSKTQHYLK-------VKKP--LLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEML 63
            |:.::.|.:..||       .|.|  |:|::||.|:|:|:..||.|:.|......:..::||.:|
Mouse    25 SSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVL 89

  Fly    64 EAALVFMR----------KQVVKQQ-------APVSPLPMDSFKNGYMNAVSEISRVMA------ 105
            |..|..::          ::::..|       :||. ..:|:|.:|:.....|:.:.:|
Mouse    90 ELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQ-ADLDAFHSGFQTCAKEVLQYLARFESWT 153

  Fly   106 -----CTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAA 165
                 |...:|         ||.....::|            ||:..|...||....:..:.:|:
Mouse   154 PREPRCAQLVS---------HLHAVATQLL------------TPQVPSGRGSGRAPCSAGAAAAS 197

  Fly   166 SPKPV 170
            .|:.|
Mouse   198 GPERV 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	19/70 (27%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	9/54 (17%)
Bhlhe41	NP_077789.1	bHLH-O_DEC2	31..122	CDD:381593	22/90 (24%)
		ORANGE	129..175	CDD:128787	10/66 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830857
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840