DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and bhlhe41

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001027504.1	Gene:	bhlhe41 / 613096	XenbaseID:	XB-GENE-994875	Length:	427	Species:	Xenopus tropicalis

Alignment Length:	186	Identity:	45/186 - (24%)
Similarity:	77/186 - (41%)	Gaps:	46/186 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FVSKTQHYLK-------VKKP--LLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAA 66
            |:.|.:..||       .|.|  |:|::||.|:|:|:..||.|:.|......:..::||.:||..
Frog    27 FLCKPKRGLKRDESKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELT 91

  Fly    67 LVFMR--KQVVKQQ------------APVSPL--PMDSFKNGYMNAVSEI-----------SRVM 104
            |..::  ..:.:||            |..||:  .:|:|.:|:.....|:           ||..
Frog    92 LKHLKGLTSLTEQQHQKIMALQNGEHALKSPIQTDLDAFHSGFQTCAKEVLQYLSRFESWTSRDQ 156

  Fly   105 ACTPAMSVDVGKTVMTHLGVEFQRMLQADQ-VQTSVTTSTPRPLSPASSGYHSDNE 159
            .||         .::.||.....::|.:.| :..||........||...|..::|:
Frog   157 RCT---------QLLNHLHTVSSQILSSSQLLLQSVPGGKGSSASPGRGGQKAENQ 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	19/62 (31%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	10/54 (19%)
bhlhe41	NP_001027504.1	bHLH-O_DEC2	30..121	CDD:381593	24/90 (27%)
bhlhe41	NP_001027504.1	ORANGE	128..168	CDD:128787	10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100