DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and hey1

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_997726.1	Gene:	hey1 / 58008	ZFINID:	ZDB-GENE-000607-70	Length:	317	Species:	Danio rerio

Alignment Length:	201	Identity:	47/201 - (23%)
Similarity:	84/201 - (41%)	Gaps:	46/201 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 APQSNNSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEML 63
            :|..:.|.:..|:.| ..|.::.::|::||.|:|..|..|:.||.   |.||.   .:::|||:|
Zfish    33 SPLGSMSPSTTSQVQ-ARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS---AKLEKAEIL 93

  Fly    64 EAA---LVFMRKQVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAM-SVD-VGKTVMTHL- 122
            :..   |..:.....|.......|.||....|:...::|.:|.::....: :.| :...:::||
Zfish    94 QMTVDHLKMLHAAGGKGYFDAHALAMDYRGLGFRECLAETARYLSIIEGLDNTDPLRIRLVSHLN 158

  Fly   123 -----------------GVEF---------QRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDS 161
                             |..|         ..:||..|.|.:       ||:.::|...|.|..|
Zfish   159 SYASQREAHSGLGHLAWGSAFGTPPSHLAHHLLLQQQQQQGA-------PLARSTSSPPSSNSSS 216

  Fly   162 QSAASP 167
            .|::||
Zfish   217 PSSSSP 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	18/57 (32%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	9/72 (13%)
hey1	NP_997726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		6/26 (23%)
		HLH	49..106	CDD:238036	18/59 (31%)
		ORANGE	119..165	CDD:128787	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..264		12/37 (32%)
		YRPW motif	307..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740