DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and HES4

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001135939.1	Gene:	HES4 / 57801	HGNCID:	24149	Length:	247	Species:	Homo sapiens

Alignment Length:	194	Identity:	46/194 - (23%)
Similarity:	79/194 - (40%)	Gaps:	51/194 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KPLLERQRRARMNKCLDTLKTLVAEFQGDDAI-------LRMDKAEMLEAA---LVFMRKQVVKQ 77
            ||::|::||||:|:.|..||||:.     ||:       .:::||::||..   |..:|:..|..
Human    65 KPVMEKRRRARINESLAQLKTLIL-----DALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTA 124

  Fly    78 QAPVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTS 142
            .....|..:..::.|:...::|::|.:|....:..||...::.||.. ..|.|...:...|::.:
Human   125 ALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAA-CLRQLGPSRRPASLSPA 188

  Fly   143 TP-----------RPLSPASSGYH-----------------SDNEDSQSAASPKPVEETMWRPW 178
            .|           |||.|:..|..                 :.....|....|       ||||
Human   189 APAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGP-------WRPW 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	20/58 (34%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	9/43 (21%)
HES4	NP_001135939.1	HLH	62..119	CDD:238036	20/58 (34%)
HES4	NP_001135939.1	Hairy_orange	136..174	CDD:284859	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840