DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m5-HLH and Heyl

DIOPT Version :9

Sequence 1:NP_524511.1 Gene:E(spl)m5-HLH / 43158 FlyBaseID:FBgn0002631 Length:178 Species:Drosophila melanogaster
Sequence 2:NP_038933.2 Gene:Heyl / 56198 MGIID:1860511 Length:326 Species:Mus musculus


Alignment Length:174 Identity:48/174 - (27%)
Similarity:71/174 - (40%) Gaps:56/174 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEMLEAALVFMRKQVVKQQAPV 81
            |.::.::|::||.|:|..|..|:.||.   |.||..   :::|||:|              |..|
Mouse    45 KKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSS---KLEKAEVL--------------QMTV 92

  Fly    82 SPLPM--DSFKNGYMNAVSEISRVMACTPAMSVD---VG-----KTVMTHLGVEFQRMLQADQVQ 136
            ..|.|  .|...|:.:|           .|::||   :|     ..|:.:|||.......||.|:
Mouse    93 DHLKMLHASGGTGFFDA-----------RALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVR 146

  Fly   137 TSVTTSTPRPLSPASSGYHSDNEDSQSAASPK--PVEETMWRPW 178
            .       |.||...| |.::.|.|.:..|..  ||    | ||
Mouse   147 I-------RLLSHLKS-YAAEMEPSPTTTSALAFPV----W-PW 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m5-HLHNP_524511.1 HLH 20..72 CDD:238036 17/54 (31%)
ORANGE 87..131 CDD:128787 11/51 (22%)
HeylNP_038933.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 2/10 (20%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 24/93 (26%)
HLH 44..100 CDD:238036 21/71 (30%)
ORANGE 115..162 CDD:128787 14/54 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..260
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..306
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830881
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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