DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and hes2.1

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	XP_021333940.1	Gene:	hes2.1 / 559147	ZFINID:	ZDB-GENE-081104-104	Length:	195	Species:	Danio rerio

Alignment Length:	205	Identity:	60/205 - (29%)
Similarity:	92/205 - (44%)	Gaps:	49/205 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQSNNSTTFVS--KTQHYL-KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDA--ILRMDKAEM 62
            |.|..|...|:  |..|.| |..|||:|::||||:|..|:.||||:....|.||  ..:::||::
Zfish    11 PHSFGSRMTVAQRKEAHELRKTLKPLMEKRRRARINDSLNHLKTLILPLVGKDASRYSKLEKADI 75

  Fly    63 LEAALVFMR---KQVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVD------VGKTV 118
            ||..:.|:|   ....|.|.       ||:|.||...:..||.::   |..:::      |.:.:
Zfish    76 LEMTVRFLRDLPSSSAKGQT-------DSYKEGYKACLQRISTML---PQSNLETEAHQRVSEFI 130

  Fly   119 MTHLG----------VEFQRML-QADQVQTSV--TTSTPRPLS--PASSGYHSDNEDSQSAASPK 168
            ...:.          .:..:|: |..|...|:  ..|...|:|  ||         .||...:|:
Zfish   131 QQSMASSSSSCQNCCAQNSKMISQMHQRLVSLRNNNSMENPISTVPA---------PSQPQPAPQ 186

  Fly   169 PVEETMWRPW 178
            ..|: |||||
Zfish   187 AAED-MWRPW 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	24/56 (43%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	10/60 (17%)
hes2.1	XP_021333940.1	HLH	30..86	CDD:306515	24/55 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940