Protein Alignment E(spl)m5-HLH and HES6

DIOPT Version :9

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_061115.2
• Gene: HES6 / 55502
• HGNCID: 18254
• Length: 224
• Species: Homo sapiens
• Alignment Length: 211
• Identity: 51/211 - (24%)
• Similarity: 84/211 - (39%)
• Gaps: 65/211 - (30%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAALVFMRKQVV-----KQQA 79
            |.:|||:|::||||:|:.|..|:.|:|   |.:...:::.||:||  |...|.|.|     :::.
Human    27 KARKPLVEKKRRARINESLQELRLLLA---GAEVQAKLENAEVLE--LTVRRVQGVLRGRARERE 86

  Fly    80 PVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHL--------GVEFQRMLQADQVQ 136
            .:.....:.|..||:..:.|:...::...|:...|...::.||        |..||.:|
Human    87 QLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLL------ 145

  Fly   137 TSVTTSTPRPLSPASSGYH--------------------SDNEDSQSA-ASPKPVE--------- 171
            .......||  :|..||:.                    ||.|::..| .|..|.|
Human   146 GDALAGPPR--APGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAAL 208

  Fly   172 ---------ETMWRPW 178
                     .::||||
Human   209 GSLTTAQIARSVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	20/51 (39%)
		ORANGE	87..131	CDD:128787	11/51 (22%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		1/3 (33%)
		HLH	23..75	CDD:238036	21/52 (40%)
		Hairy_orange	96..134	CDD:311465	8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..205		12/59 (20%)
		WRPW motif	221..224		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700