Protein Alignment E(spl)m5-HLH and HES2

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 169
• Identity: 51/169 - (30%)
• Similarity: 83/169 - (49%)
• Gaps: 20/169 - (11%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQG--DDAILRMDKAEMLEAALVFMRKQVVKQQAPVS 82
            |..|||||::||||:|:.|..||.|:....|  :....:::||::||..:.|:::.........:
Human    15 KSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAA 79

  Fly    83 PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQR----MLQADQVQTSVTTST 143
            |||.||::.||...|:.::||:.....:...|...::.||   ::|    .|...:...|...|.
Human    80 PLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHL---WRRAASATLDGGRAGDSSGPSA 141

  Fly   144 PRPLSPASSGYHSDNEDSQSAASPKPVEET----MWRPW 178
            |.| :|||:      .:..||..|.|....    :||||
Human   142 PAP-APASA------PEPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	21/59 (36%)
		ORANGE	87..131	CDD:128787	11/47 (23%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	21/58 (36%)
		ORANGE	84..127	CDD:128787	11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		14/51 (27%)
		WRPW motif	170..173		2/2 (100%)