Protein Alignment E(spl)m5-HLH and HES2

DIOPT Version :9

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 169
• Identity: 51/169 - (30%)
• Similarity: 83/169 - (49%)
• Gaps: 20/169 - (11%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQG--DDAILRMDKAEMLEAALVFMRKQVVKQQAPVS 82
            |..|||||::||||:|:.|..||.|:....|  :....:::||::||..:.|:::.........:
Human    15 KSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAA 79

  Fly    83 PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQR----MLQADQVQTSVTTST 143
            |||.||::.||...|:.::||:.....:...|...::.||   ::|    .|...:...|...|.
Human    80 PLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHL---WRRAASATLDGGRAGDSSGPSA 141

  Fly   144 PRPLSPASSGYHSDNEDSQSAASPKPVEET----MWRPW 178
            |.| :|||:      .:..||..|.|....    :||||
Human   142 PAP-APASA------PEPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	21/53 (40%)
		ORANGE	87..131	CDD:128787	11/47 (23%)
HES2	NP_061962.2	HLH	12..70	CDD:238036	21/54 (39%)
		ORANGE	84..127	CDD:128787	11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		14/51 (27%)
		WRPW motif	170..173		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140926
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5317
OMA	1	1.010	-	-		QHG47782
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800