DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and hey1

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001007911.1	Gene:	hey1 / 493293	XenbaseID:	XB-GENE-486694	Length:	300	Species:	Xenopus tropicalis

Alignment Length:	163	Identity:	37/163 - (22%)
Similarity:	67/163 - (41%)	Gaps:	22/163 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEMLEAA---LVFMRKQVVKQQ 78
            |.::.::|::||.|:|..|..|:.||.   |.||.   .:::|||:|:..   |..:.....|..
Frog    50 KRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS---AKLEKAEILQMTVDHLKMLHTAGGKGY 111

  Fly    79 APVSPLPMDSFKNGYMNAVSEISRVMACTPAMSV--DVGKTVMTHLGVEFQRMLQADQVQTSV-- 139
            .....|.||....|:...::|::|.::....|..  .:...:::||.....:...|:...|.:
Frog   112 FDAHALAMDYRSLGFRECLAEVARYLSIIEGMDTTDPLRVRLVSHLNNYASQREAANTAHTGIGH 176

  Fly   140 ---------TTSTPRPLSPASSGYHSDNEDSQS 163
                     ......||..|.:.:.|.|..|.|
Frog   177 IPWGGTFAHHPHLSHPLLLAQTAHTSANSTSSS 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	18/57 (32%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	7/45 (16%)
hey1	NP_001007911.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		1/1 (100%)
		bHLH_SF	40..121	CDD:381792	21/73 (29%)
		ORANGE	119..165	CDD:128787	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..232		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..300
		YRPW motif	290..293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910