DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and helt

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_996948.1	Gene:	helt / 404275	ZFINID:	ZDB-GENE-040824-6	Length:	270	Species:	Danio rerio

Alignment Length:	169	Identity:	37/169 - (21%)
Similarity:	67/169 - (39%)	Gaps:	41/169 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VKKPLLERQRRARMNKCLDTL-KT----LVAEFQGDDAILRMDKAEMLEAALVFMRK-------- 72
            |...::|::||.|:|:||:.| ||    |..:..|     :::|||:||..:.::|.
Zfish    62 VSHKVIEKRRRDRINRCLNELGKTVPMALAKQNSG-----KLEKAEILEMTVQYLRALHSADFPR 121

  Fly    73 -----QVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQA 132
                 :::.:.|       :.|..||...:..:  |...|....::...|....:....|..:..
Zfish   122 GREKGELLTEFA-------NYFHYGYHECMKNL--VHYLTTVERMETKDTKYARILAFLQSKVVT 177

  Fly   133 DQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVE 171
            :.|..|:.|.:|.|         :|........||.|.|
Zfish   178 EPVFGSLGTISPDP---------TDLLCQLEYQSPSPTE 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	18/55 (33%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	7/43 (16%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		HLH	62..115	CDD:278439	19/57 (33%)
		Hairy_orange	136..173	CDD:284859	6/38 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740