DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m5-HLH and HES3

DIOPT Version :9

Sequence 1:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_001019769.1	Gene:	HES3 / 390992	HGNCID:	26226	Length:	186	Species:	Homo sapiens

Alignment Length:	194	Identity:	45/194 - (23%)
Similarity:	74/194 - (38%)	Gaps:	57/194 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LERQRRARMNKCLDTLKTLVAEFQGDDAILR-MDKAEMLEAALVFMRKQVVKQQAPVSPLPMDSF 89
            :|::||||:|..|:.||:|:.:........| ::||::||.::.:||......|. :.|:|
Human     1 MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQG-LWPVP---- 60

  Fly    90 KNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTSTP---------- 144
                 ....:.|...:|.|      |.:.:...|.|....|:...|..|...||.
Human    61 -----RGAEQPSGFRSCLP------GVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAP 114

  Fly   145 ---RPL-------SPASSGYHS--------DNEDSQSAASPKPVEET------------MWRPW 178
               ||.       :||:.|..|        ::....||:.|.|...:            :||||
Human   115 ALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCAESPGLGLRVWRPW 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	16/46 (35%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	6/43 (14%)
HES3	NP_001019769.1	HLH	1..54	CDD:238036	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..186		12/51 (24%)
		WRPW motif	175..178		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840