Protein Alignment E(spl)m5-HLH and HES5

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 226
• Identity: 44/226 - (19%)
• Similarity: 77/226 - (34%)
• Gaps: 86/226 - (38%)

  Fly     1 MAPQSNNSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLV-AEFQGDDAILRMDKAEMLE 64
            ::|:..|            :::||::|:.||.|:|..::.||.|: .||.......:::||::||
Human    11 LSPKEKN------------RLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILE 63

  Fly    65 AALVFMR----------KQVVKQQAPVSPLPM----------------------DSFKNGYMNAV 97
            .|:.:::          :.....:||..|.|.                      ..:..||...:
Human    64 MAVSYLKHSKGERARAPRAPSSHRAPAPPRPAARSPPPRLPAAFVAAAGPKSLHQDYSEGYSWCL 128

  Fly    98 SEISRVMACTPAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDSQ 162
            .|  .|...|...:.|....::.|    |||                .|.:||:..    .|...
Human   129 QE--AVQFLTLHAASDTQMKLLYH----FQR----------------PPAAPAAPA----KEPKA 167

  Fly   163 SAASPKPVEET---------------MWRPW 178
            ..|:|.|....               :||||
Human   168 PGAAPPPALSAKATAAAAAAHQPACGLWRPW 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	17/68 (25%)
		ORANGE	87..131	CDD:128787	10/43 (23%)
HES5	XP_005244808.1	bHLH-O_HES5	18..74	CDD:381467	17/55 (31%)
		Hairy_orange	118..153	CDD:470640	8/40 (20%)