Protein Alignment E(spl)m5-HLH and Hes1

DIOPT Version :9

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_077336.3
• Gene: Hes1 / 29577
• RGDID: 62081
• Length: 281
• Species: Rattus norvegicus
• Alignment Length: 262
• Identity: 55/262 - (20%)
• Similarity: 98/262 - (37%)
• Gaps: 86/262 - (32%)

  Fly     3 PQSNNSTTFVSKT-QHYLKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAI--LRMDKAEMLE 64
            |.|.|:|....|| ..:.|..||::|::||||:|:.|..||||:.:....|:.  .:::||::||
  Rat    18 PASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILE 82

  Fly    65 AALVFMRK-QVVKQQAPVS--PLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLG--- 123
            ..:..:|. |..:..|.:|  |..:..::.|:...::|::|.::....::.:|...::.||.
  Rat    83 MTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCM 147

  Fly   124 VEFQRMLQADQVQTSVTTSTPRPLS---------------------------------------- 148
            .:...|....|...::....|.|.|
  Rat   148 TQINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGE 212

  Fly   149 -----------PASSG--------------------YHSDNEDS--QSAASPKP----VEETMWR 176
                       ||..|                    |.|::..|  .:|.||..    ..::|||
  Rat   213 AAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWR 277

  Fly   177 PW 178
            ||
  Rat   278 PW 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	19/53 (36%)
		ORANGE	87..131	CDD:128787	7/46 (15%)
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		9/25 (36%)
		bHLH-O_HES1_4	33..95	CDD:381465	21/61 (34%)
		Hairy_orange	110..148	CDD:400076	6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..206		4/47 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..281		9/25 (36%)
		WRPW motif	276..279		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840