Protein Alignment E(spl)m5-HLH and Hes2

DIOPT Version :10

• Sequence 1: NP_524511.1
• Gene: E(spl)m5-HLH / 43158
• FlyBaseID: FBgn0002631
• Length: 178
• Species: Drosophila melanogaster
• Sequence 2: NP_062109.1
• Gene: Hes2 / 29567
• RGDID: 62082
• Length: 157
• Species: Rattus norvegicus
• Alignment Length: 165
• Identity: 50/165 - (30%)
• Similarity: 84/165 - (50%)
• Gaps: 28/165 - (16%)

  Fly    20 KVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDA--ILRMDKAEMLEAALVFMRKQVVKQQAPVS 82
            |..|||||::||||:|:.|..||.||....|.:.  ..:::||::||..:.|:|:|.....:..:
  Rat    15 KSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCSTEA 79

  Fly    83 PLPMDSFKNGYMNAVSEISRVM-ACT---PAMSVDVGKTVMTHLGVEFQRMLQADQVQTSVTTST 143
            |..:||:..||...::.::||: ||:   ||:|.               |:|  :.::....:..
  Rat    80 PGSLDSYLEGYRACLARLARVLPACSVLEPAVSA---------------RLL--EHLRQRTVSGG 127

  Fly   144 PRPLSPASSGYHSDNEDSQSAASPKPVEETMWRPW 178
            |..|:|||:     :..:.|...|.|....:||||
  Rat   128 PPSLTPASA-----SAPAPSPPVPPPSSLGLWRPW 157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m5-HLH	NP_524511.1	bHLH-O_ESM5_like	20..78	CDD:381486	24/59 (41%)
		ORANGE	87..131	CDD:128787	12/47 (26%)
Hes2	NP_062109.1	bHLH_SF	10..73	CDD:469605	24/57 (42%)
		ORANGE	84..128	CDD:128787	13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..157		10/37 (27%)
		WRPW motif	154..157		2/2 (100%)